Ethical Allocation of Remdesivir

Ethical allocation of preexposure HIV prophylaxis.

Bandit Strategies for Ethical Sequential Allocation

The problem of allocating patients in a two treatment clinical trial with dichotomous response is considered. The trial goal is to determine the better treatment while incurring as few patient losses as possible. Several allocation rules are compared and it is found that bandit strategies perform well on both criteria in that they achieve nearly optimal power while keeping expected trial failur...

Ethical framework for resource allocation during a drug supply shortage.

Drug supply shortages are common in health systems due to manufacturing and other delays. Frequently, shortages are successfully addressed through conservation and redistribution efforts, with limited impact on patient care. However, when Sandoz Canada Inc. announced in February 2012 that it was reducing production of a number of generic injectable drugs at its Quebec facility, the scope and ma...

Preemptive kidney transplantation: an ethical challenge for organ allocation policies.

Preemptive transplants are advisable in advanced stages of kidney disease. The clinical advantages of preemptive transplantation over dialysis are evident. Nevertheless, preemptive transplantations raise ethical concerns, particularly regarding the allocation of medical resources. The present article proposes some criteria for organ allocation policies regarding preemptive transplantations: cri...

Beyond the numbers: rational and ethical application of outcome models for organ allocation in liver transplantation.

Applying predictive models to heath policy—particularly when allocating scarce life-saving resources— must be understood in the context of clinical practice patterns and ethical principles. Unlike most medical and surgical interventions in the developed world, the availability of liver transplantation (LTx) is limited by the supply of scarce donor organs rather than monetary resources or the nu...